By M. Goulon (auth.), Prof. Antonino Gullo M.D. (eds.)
The administration of the severely in poor health sufferers has been some time past few years a self-discipline on the vanguard of improvement which maintains to make development with the help of simple and scientific learn. This paintings is a set of fabric that offers with the administration of severely unwell sufferers, released at the celebration of the thirteenth APICE congress in November 1998, which celebrated forty years of serious Care Medicine.
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Extra resources for Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.: Proceedings of the 13th Postgraduate Course in Critical Care Medicine Trieste, Italy — November 18–21, 1998
Safar 69. Capone A, Safar P, Radovsky A et al (1996) Complete recovery after normothermic hemorrhagic shock and profound hypothermic circulatory arrest of 60 minutes in dogs.
Proof of no or only moderate benefit in some cases seems impossible with randomized clinical outcome studies of CA patients. A breakthrough effect would be so obvious that randomly withholding the novel treatment raises questions of ethics. CA-outcome studies in reproducible large animal models with intensive care, should be accepted as "clinical trials" and be followed by feasibility and side effect studies in sick humans, before general use. Other drugs were evaluated in incomplete forebrain ischaemia rat models [43,44], the asphyxial cardiac arrest rat model , GBI models in monkeys [8, 16,34,35,41] and the clinically most relevant CA models in dogs with intensive care and outcome evaluation [8, 25, 38,48].
We also recognize the errors or mistakes made in the care of our patients in intensive care units, and it behooves all of us to make decisions to provide fail-safe symptoms as best we can. All of our institutions have broad-based committees involved in reviewing research proposals and other facets of intensive care unit ethics. It is important to point out, however, that there is both informed consent and informed refusal. A patient may refuse to accept therapy based upon his or her own beliefs and approach to life.