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Bioaccumulation - New Aspects and Developments by B. Beek

By B. Beek

The bioaccumulation of endocrine disruptors, continual natural chemical compounds and different compounds of excessive environmental impression has develop into of accelerating curiosity in most modern environmental examine, hazard research and toxicology. This quantity supplies an up to date evaluate and introduces the reader to the recent proposal of "internal impression focus" linking bioaccumulation and biomagnification within the meals chain to ecotoxicology and hazard evaluate.

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Abbreviations of the chemicals: p,p¢-DDT; 2,2-bis-(p-chlorophenyl)-1,1,1-trichloroethane. OCDD; octachlorodibenzo-p-dioxin. TCDD; tetrachlorodibenzo-p-dioxin. HCB; hexachlorobenzene. PCA; pentachloroanisole. PeCB; pentachlorobenzene. MX; musk xylene. TeCB; tetrachlorobenzene. NP; nonylphenol. TCB; tetrachlorobenzene. g-HCH; g-hexachlorocyclohexane (Lindane). PCP; pentachlorophenol. DCB; dichlorobenzene. BPA; bisphenol-A. PCBs; polychlorinated biphenyls pendent and independent variables the geometric mean (GM) functional regression method published by Halfon [77b] was also used (see equation in Table 4).

Geyer et al. Fig. 10. Biosynthesis and main metabolic pathways of natural male and female steroidal sex hormones (androgens and estrogens) starting with cholesterol. The main enzymes, which catalyze these reactions, are given in angular brackets. Taken with modifications from Forth et al. [175], Schlumpf and Lichtensteiger [176], Turan [177], Bradlow et al. J. Geyer et al. ethoxylates (APEs) and their degradation products, the alkylphenols, such as nonylphenol, octylphenol etc. [128, 129]. Recently it was shown by Shelby et al.

J. Geyer et al. Recently, it was found by Kelce et al. [125a] that the persistent p,p¢-DDT metabolite p,p¢-DDE is a potent androgen receptor antagonist. This compound is highly hydrophobic and has a very high bioconcentration potential. Furthermore, it is important to note that also estrogens, such as estradiol, diethylstilbestrol, Kepone, o,p¢-DDT, and methoxychlor can bind also to the androgen receptor [125b]. 5 Chemicals Which Interact with Different Hormonal Receptors and/or Hormone-Binding Proteins It is known that natural and synthetic steroidal hormones can interact with more than one steroid receptor and exert different physiological actions in organisms.

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