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Biomaterials as Stem Cell Niche by Sarah E. Stabenfeldt, Ashley Carson Brown (auth.),

By Sarah E. Stabenfeldt, Ashley Carson Brown (auth.), Krishnendu Roy (eds.)

Recent advancements in stem mobilephone biology have opened new instructions in mobile treatment. This e-book offers the state of the art advancements in utilizing biomaterials as synthetic niches for engineering stem cells, either for the aim of higher realizing their biology lower than 3D biomimetic stipulations in addition to for constructing new options for effective long-term upkeep and directed differentiation of stem cells into a variety of healing lineages. Animal and human stem cells of either embryonic and grownup foundation are mentioned with purposes starting from nerve regeneration, orthopedics, cardiovascular treatment, blood mobile new release and melanoma treatment. either man made and usual biomaterials are reviewed with emphasis on how material-stem telephone interactions direct particular signaling pathways and finally modulate the cellphone destiny. This ebook is effective for biomaterial scientists, tissue engineers, clinicians in addition to stem mobilephone biologists desirous about simple examine and functions of grownup and embryonic stem cells.

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Adv. Drug Deliv. Rev. 60(2), 199 214 (2008) 3. , et al. (eds): Principles of Regenerative Medicine, vol. 1448. Elsevier, Burlington (2008) 4. : Generation of germline competent induced pluripotent stem cells. Nature 448(7151), 313 317 (2007) 5. : Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5), 861 872 (2007) 6. : Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4), 663 676 (2006) 7.

261(1), 91 103 (2000) 24. : Poly(D,L lactic acid) poly(ethylene glycol) monomethyl ether diblock copolymers control adhesion and osteoblastic differentiation of marrow stromal cells. Tissue Eng. 9(1), 71 84 (2004) 25. : Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell 6(4), 483 495 (2004) 26. : The effect of glow discharge plasma surface modification of polymers on the osteogenic differentiation of committed human mesenchymal stem cells. Biomaterials 27(10), 2258 2264 (2006) 27.

In addition to this, several studies have illustrated the ability of similar functional materials to recruit progenitor cells and promote the formation of new tissue in vivo, particularly cartilage and bone tissue. A study by Sharma et al. demonstrates in vivo chondrogensis of goat MSCs encapsulated in photopolymerized PEG hydrogels containing hyaluronic acid (HA) along with TGF-b, followed by the generation of cartilage-specific ECM (specifically collagen II and proteoglycan) upon subcutaneous injection into athymic nude mice [111].

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