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CD137 Pathway: Immunology and Diseases by Lieping Chen

By Lieping Chen

The immune approach has developed largely to let organisms to withstand microbial an infection. Microorganisms have lengthy been used as experimental instruments by way of immunologists, and the research of the immune responses to viruses, sickness and micro organism has contributed a lot to our knowing of easy immunological mechanisms. the main functional and scientific purposes for trying to comprehend the immunology of infections and disorder revolves round the CD137 and CD137/41BB receptor and ligand molecules. those fundamental antibodies include new pathway and play significant roles within the keep an eye on of immune responses. in recent times, this pathway is rising as one for an important pursuits for manipulation of immune responses for ailment prognosis and remedy.

Dr. Chen stumbled on the CD-137 and B7H1 molecules in 1999 and his lab lately pointed out and defined a brand new member of the $64000 B7 kinfolk of immune procedure costimulatory molecules. he's the main professional within the box. This booklet will hide all elements of CD137/4-1BB pathway examine from microbiology, infectious sickness, molecular biology, biochemistry, and genetics to immune responses and strength functions within the analysis and therapy of human ailments together with cancers, autoimmune ailments, viral an infection and transplantation rejection.

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At the first antigen encounter the CD40 receptor/ligand system costimulates B cell proliferation and immunoglobulin class switch. At the second antigen encounter during affinity maturation the CD137 receptor/ligand system costimulate B cell proliferation and immunoglobulin synthesis. FDC: follicular dendritic cell. These functional data on CD137 ligand-mediated B cell activation are supported by histological findings. , 2002). B cells accumulate after first antigen encounter in these anatomical structures and undergo the process of affinity maturation.

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity, 9, 669–676. , and Takei, F. (2003). Membrane cholesterol regulates LFA-1 function and lipid raft heterogeneity. Blood, 102, 215–222. A. (1994). Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. , 8, 1759–1771. , and Chen, L. (1997). Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat. , 3, 682–685. Michael, C.

Cellular and Molecular Immunology. B. Saunders, Philadelphia, Pennsylvania. M. (2001). Growth factor-stimulated phosphorylation of Akt and p70S6K is differentially inhibited by LY294002 and wortmannin. Endocrinology, 142, 498–501. A. A. (2002). CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activating of the PI3K/PKB signaling pathway in primary human T cells. J. , 168, 2729–2736. B. (1998). 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor κB.

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