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Gastroesophageal reflux diseases by Frank Alexander Granderath, Thomas Kamolz, Rudolph Pointner

By Frank Alexander Granderath, Thomas Kamolz, Rudolph Pointner

Gastroesophageal reflux ailment (GERD) is among the commonest issues with an expanding occurrence and prevalence within the final twenty years. This ebook, edited via skilled surgeons and a medical psychologist in cooperation with a number of around the globe prime specialists, offers clinically proper info for gastroenterologists, internists, surgeons, citizens and likewise nurses, who often deal with GERD sufferers. targeting various therapy ideas – clinical, endoscopic in addition to surgical – the chapters comprise the fundamentals of symptomatology and epidemiology, pathophysiology, GERD between varied age teams, issues and its remedy, hiatal hernia or H. pylori and GERD, NERD and useful heartburn, diagnostic approaches and in addition presurgical exam. additionally, the patient's views of ailment, diagnostics and therapy are integrated, just like monetary points of GERD, and the influence of ailment on caliber of existence or patient-reported results after therapy.

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Multiple studies have found that age increases with increasing severity of esophagitis. Authors have reported the mean age of patients with BE to be 61, those with stricture have a mean age of 63–65, and for esophageal ulcer, the mean age is 60–62 [17], [39], [55], [60]. 5 [55]. Reynolds noted that although GERD related ulcerations are rare in younger patients, they occur in up to 20–30% of older individuals [61]. 4% of patients younger than 64 [40]. 18 per 10 year increase [59]. As the severity of esophagitis increases, there is an increase in the proportion of patients with severe heartburn and heartburn Ͼ 5 years in duration [62].

These authors found that 41% and 30% of patients reported non-cardiac chest pain and cough, respectively. Raiha et al studied the prevalence of GERD symptoms in elderly patients referred for endoscopy [12]. They found regurgitation in less than 25%, heartburn in 36%, dysphagia in 20%, and 37% of their subjects reported atypical reflux symptoms. At least two studies have found an increase in dysphagia with increasing age [4], [13]. Those with dysphagia report symptoms for a shorter period of time than those with heartburn, suggesting that dysphagia may be a late manifestation of GERD.

Gastroenterology 111: 1200–1205 [44] Orlando RC (1999) Pathophysiology of gastroesophageal reflux disease. ), 3rd ed. Philadelphia: Lippincot Williams & Wilkins, p 409–419 [45] Hollerbach S, Bulat R, May A, Kamath MV, Upton AR, Fallen EL, Tougas G (2000) Abnormal cerebral processing of oesophageal stimuli in patients with noncardiac chest pain (NCCP). Neurogastroenterol Motil 12: 555–565 [46] Sarkar S, Aziz Q , Woolf CJ, Hobson AR, Thompson DG (2000) Contribution of central sensitisation to the development of non-cardiac chest pain.

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