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Hormone Replacement Therapy and The Brain (Controversial by Andrea R. Genazzani

By Andrea R. Genazzani

In recent times there was elevated curiosity within the risk that hormone alternative remedy can have an important influence on neurological functionality within the getting older lady. it's been hypothesized that estrogens may also have a protecting position within the onset of Alzheimer's or different dementias. This quantity attracts jointly major specialists to check the prevailing medical info and current a consensus view that would be a pragmatic relief to clinicians. The publication bargains a state of the art precis of present wisdom that provides readers a greater knowing of the aptitude advantages of hormone remedy whilst treating Alzheimer's and different dementias.

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Improta-Brears T, Whorton AR, Codazzi F, et al. Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. Proc Natl Acad Sci USA 1999; 96:4686–91 22. Schmidt R, Fazekas F, Reinhart B, et al. Estrogen replacement therapy in older women: a neuropsychological and brain MRI study. J Am Geriatr Soc 1996; 44:1307– 13 23. Behl C. Estrogen—Mystery Drug for the Brain? The Neuroprotective Activities of the Female Sex Hormone. Vienna: Springer, 2001:228 24.

Mitochondria and calcium: from cell signalling to cell death. J Physiol 2000; 529: 57–68 107. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997; 275:1132–6 108. Murphy AN, Bredesen DE, Cortopassi G, Wang E, Fiskum G. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci USA 1996; 93:9893–8 109. Murphy AN. Ca(2+)-mediated mitochondrial dysfunction and the protective effects of Bcl-2.

Schmidt R, Fazekas F, Reinhart B, et al. Estrogen replacement therapy in older women: a neuropsychological and brain MRI study. J Am Geriatr Soc 1996; 44:1307– 13 23. Behl C. Estrogen—Mystery Drug for the Brain? The Neuroprotective Activities of the Female Sex Hormone. Vienna: Springer, 2001:228 24. Singh M. Ovarian hormones elicit phosphorylation of Akt and extracellular-signal regulated kinase in explants of the cerebral cortex. Endocrine 2001; 14:407–15 25. Wade CB, Robinson S, Shapiro RA, Dorsa DM.

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