By Vincent Descombes
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Extra info for Lo mismo y lo otro: Cuarenta Y Cinco Anos De Filosofia Francesa 1933-1978
In both pathways, this clonal expansion includes memory ce illustrated i MM CD8+ CD8+ cytot to cells expr by class I M characteriz T cells. The ecules on a CD8+ cells synthesis o cell is accom facilitates e MM Supe A group of number of sity. This ca ability to b out involvi portions de Vβ regions CHAPTER 2 IMMUNE RESPONSE TO INFECTION MHC Class I MHC Class II ER Intracellular antigen (virus) Antigen processing to peptides in proteasome 33 Cytoplasm Extracellular antigen (bacteria) Endocytic vesicle Peptide production in phagolysosome Nucleus Proteasome Peptide binding by MHC class II Peptide transport into endoplasmic reticulum (ER) MHC class ll in vesicle Peptide binding by MHC class I MHC class II presents peptide at cell surface Golgi MHC class I presents peptide at cell surface FIGURE 2–11.
Memory cells along with the T cells committed to effector functions. These pathways are illustrated in Figure 2–13. MM CD8+ Cytotoxic T Lymphocytes CD8+ cytotoxic T lymphocytes (CTLs) are a second class of effector T cells. They are lethal to cells expressing the epitope against which they are directed when the epitope is presented by class I MHC molecules. They too have specific epitope recognition sites, but they are characterized by the CD8 cell surface marker; thus, they are referred to as CD8+ cytotoxic T cells.
Memory cells are not produced, and T-independent responses mature more slowly than T-dependent responses. This delay in maturation may contribute to the increased susceptibility to some bacterial infections in early life. It certainly contributed to the failure of purified polysaccharide vaccines to effectively immunize children younger than 2 years. For use in children, these vaccines have been replaced with a hapten approach in which the polysaccharide is conjugated to protein. In this form, antibody generated by the T-dependent mechanism (protein carrier) still has specificity for the polysaccharide epitopes.