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Neuronal Network Dynamics in 2D and 3D in vitro by Monica Frega

By Monica Frega

The e-book provides a brand new, robust version of neuronal networks, which includes a third-dimensional neuronal tradition within which 3D neuronal networks are coupled to micro-electrode-arrays (MEAs). It discusses the most benefits of the 3-dimensional method in comparison to its two-dimensional counterpart, and indicates that the community dynamics, recorded in the course of either spontaneous and encouraged task, differs among the 2 versions, with the 3D procedure being higher in a position to emulate the in vivo behaviour of neural networks. The booklet bargains an intensive research of the process, from the theoretical heritage, to its layout and purposes in neuro-pharmacological reviews. additionally, it incorporates a concise but finished advent to either second and 3D neuronal networks coupled to MEAs, and discusses the benefits, boundaries and demanding situations in their functions as mobile and tissue-like in vitro experimental version systems.

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Extra resources for Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems

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Although the presence of such a strong intrinsic dynamics, the brain is able to perform useful information processing. Recent studies suggested that the synchronized state of a network leads to increased adaptation to prolonged or rapidly repeated stimuli. When the ongoing dynamic is desynchronized, instead, the system is putted under progressively greater control of sensory stimuli. The role of intrinsic dynamics in shaping population activity is toned down. In any case it should be underlined that, generally, neuronal network preparations are far to the real brain structure: networks do not follow a specific architecture and any peculiar brain structure architecture is missing.

Other authors (Jimbo et al. 1993; Suzuki et al. 2004, 2005; Macis et al. 2007; Marconi et al. 2012) proposed to couple micro-patterning techniques to extracellular recordings by means of MEAs. In this case, micromachining or patterning is used to define the network architecture by arranging cell bodies and cell processes onto the microelectrodes. In particular, Macis and coworkers developed a system for neuronal network patterning on MEA devices (Macis et al. 2007). By using this technique it is possible to change the architecture of the network.

Each module also contains highly connected nodes with mainly intramodular connections. The diagrams at the bottom illustrates the concepts of a network path (between nodes 1 and 2) and clustering (around node 3). Adapted from Sporns (2011) to drive the network towards dynamic states characterized by synchronous/asyn‐ chronous features. 3. The capability of neural systems to encode and process incoming stimuli is affected by both structure and ongoing dynamics (Marguet and Harris 2011). e. without applying any kind of electrical or chemical stimulation they present an ongoing activity which configures the brain as a noisy-entity.

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