By Atsushi Kumanogoh
This booklet provides the present ideas of semaphorin biology. within the early Nineties, semaphorins have been initially pointed out as axon counsel cues that functionality in the course of neuronal improvement. notwithstanding, cumulative findings have clarified that they have got varied features in lots of physiological tactics, together with cardiogenesis, angiogenesis, vasculogenesis, osteoclastogenesis, retinal homeostasis, and immune legislation. also, they've been implicated within the pathogenesis of varied human ailments, together with tumorigenesis/tumor metastasis, neuroregenerative ailments, retinal degeneration, abnormal pulse/sudden loss of life, and immune issues. in keeping with this present study history, the ebook covers the basic state of the art findings for uncomplicated scientists in biochemistry, molecular biology, neuroscience, developmental biology, and structural biology, in addition to for physicians in neurology, cardiology, oncology, orthopedic surgical procedure, otorhinolaryngology, ophthalmology, allergology, and rheumatology.
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Extra info for Semaphorins: A Diversity of Emerging Physiological and Pathological Activities
Neuron 56(5):807–822 Cioni JM, Telley L, Saywell V, Cadilhac C, Jourdan C, Huber AB, Huang JZ, Jahannault-Talignani C, Ango F (2013) SEMA3A signaling controls layer-specific interneuron branching in the cerebellum. Curr Biol 23(10):850–861 Cloutier JF, Giger RJ, Koentges G, Dulac C, Kolodkin AL, Ginty DD (2002) Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons. Neuron 33(6):877–892 Cloutier JF, Sahay A, Chang EC, Tessier-Lavigne M, Dulac C, Kolodkin AL, Ginty DD (2004) Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections.
Cell 149(7):1594–1606 Sakai JA, Halloran MC (2006) Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish. Development 133(6):1035–1044 Sanes JR, Yamagata M (2009) Many paths to synaptic specificity. Annu Rev Cell Dev Biol 25:161–195 Sanes JR, Zipursky SL (2010) Design principles of insect and vertebrate visual systems. Neuron 66(1):15–36 Schwarting GA, Kostek C, Ahmad N, Dibble C, Pays L, Puschel AW (2000) Semaphorin 3A is required for guidance of olfactory axons in mice.
2011). These studies provide further evidence that L1 adhesion molecule family members are important modulators of semaphorin-regulated axon guidance. In addition to sculpting the overall trajectories that define a wide range of axon tracts in the mammalian brain, semaphorins also play instrumental roles in controlling the precise innervation of laminated structures in the brain. In the cerebellum, basket cells located in the molecular layer densely innervate the axon hillock of Purkinje cells located in the Purkinje cell layer (PCL).