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Additional info for Taste and Smell
Science 299(5615):2054–2058 53. Elliott RA, Kapoor S, Tincello DG (2011) Expression and distribution of the sweet taste receptor isoforms T1R2 and T1R3 in human and rat bladders. J Urol 186(6):2455–2462. 083 54. Masubuchi Y, Nakagawa Y, Ma J, Sasaki T, Kitamura T, Yamamoto Y, Kurose H, Kojima I, Shibata H (2013) A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. PLoS One 8(1):e54500. 0054500 55. Simon BR, Parlee SD, Learman BS, Mori H, Scheller EL, Cawthorn WP, Ning X, Gallagher K, Tyrberg B, Assadi-Porter FM, Evans CR, MacDougald OA (2013) Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.
J Vet Med Sci 66(11):1311–1314 119. Hofer D, Drenckhahn D (1998) Identification of the taste cell G-protein, alpha-gustducin, in brush cells of the rat pancreatic duct system. Histochem Cell Biol 110(3):303–309 120. Ruiz-Avila L, McLaughlin SK, Wildman D, McKinnon PJ, Robichon A, Spickofsky N, Margolskee RF (1995) Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells. Nature 376(6535):80–85 121. Hofer D, Asan E, Drenckhahn D (1999) Chemosensory perception in the gut.
Gerbe F, Legraverend C, Jay P (2012) The intestinal epithelium tuft cells: specification and function. Cell Mole Life Sci 69(17):2907–2917. 1007/s00018-012-0984-7 128. Luciano L, Reale E, Ruska H (1968) On a glycogen containing brusc cell in the rectum of the rat. Z Zellforsch Mikrosk Anat 91(1):153–158 129. Sternini C, Anselmi L, Rozengurt E (2008) Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes 15(1):73–78 130. -12 from Hoodia gordonii activates the human bitter receptor TAS2R14 and induces CCK release from HuTu80 cells.