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Taste and Smell by Dietmar Krautwurst (eds.)

By Dietmar Krautwurst (eds.)

Medicinal chemistry is either technological know-how and artwork. The technological know-how of medicinal chemistry bargains mankind one in all its most sensible hopes for making improvements to the standard of lifestyles. The artwork of medicinal chemistry maintains to problem its practitioners with the necessity for either instinct and adventure to find new medicines. for that reason sharing the adventure of drug study is uniquely precious to the sphere of medicinal chemistry. Drug study calls for interdisciplinary team-work on the interface among chemistry, biology and medication. for that reason, the topic-related sequence issues in Medicinal Chemistry covers all appropriate points of drug study, e.g. pathobiochemistry of ailments, id and validation of (emerging) drug pursuits, structural biology, drugability of ambitions, drug layout methods, chemogenomics, man made chemistry together with combinatorial tools, bioorganic chemistry, traditional compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions at the molecular point, structure-activity relationships, drug absorption, distribution, metabolism, removal, toxicology and pharmacogenomics. typically, designated volumes are edited through renowned visitor editors.

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Science 299(5615):2054–2058 53. Elliott RA, Kapoor S, Tincello DG (2011) Expression and distribution of the sweet taste receptor isoforms T1R2 and T1R3 in human and rat bladders. J Urol 186(6):2455–2462. 083 54. Masubuchi Y, Nakagawa Y, Ma J, Sasaki T, Kitamura T, Yamamoto Y, Kurose H, Kojima I, Shibata H (2013) A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. PLoS One 8(1):e54500. 0054500 55. Simon BR, Parlee SD, Learman BS, Mori H, Scheller EL, Cawthorn WP, Ning X, Gallagher K, Tyrberg B, Assadi-Porter FM, Evans CR, MacDougald OA (2013) Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.

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Gerbe F, Legraverend C, Jay P (2012) The intestinal epithelium tuft cells: specification and function. Cell Mole Life Sci 69(17):2907–2917. 1007/s00018-012-0984-7 128. Luciano L, Reale E, Ruska H (1968) On a glycogen containing brusc cell in the rectum of the rat. Z Zellforsch Mikrosk Anat 91(1):153–158 129. Sternini C, Anselmi L, Rozengurt E (2008) Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes 15(1):73–78 130. -12 from Hoodia gordonii activates the human bitter receptor TAS2R14 and induces CCK release from HuTu80 cells.

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