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Textbook of Neuro-Oncology by Berger M.S., Prados M.

By Berger M.S., Prados M.

Explores all the such a lot not easy neurologic cancers that clinicians face

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According to the WHO scheme, tumors with nuclear atypia alone are considered grade II; those with mitotic activity in addition to nuclear atypia are grade III; and neoplasms showing atypia, mitoses, microvascular hyperplasia (“endothelial proliferation”), or necrosis are considered grade IV. The WHO classification recognizes three morphologic variants of cells comprising diffuse astrocytomas: fibrillary, protoplasmic, and gemistocytic. However, no cytoarchitectural variant appears to have any prognostic importance.

Dagher AP, Smirniotopoulos J: Tumefactive demyelinating lesions. Neuroradiology 38:560–565, 1996. 4. Daumas-Duport C, Scheithauer B, O’Fallon J, Kelly P: Grading of astrocytomas: a simple and reproducible method. Cancer 62:2152–2165, 1988. 5. Eby NL, Grufferman S, Flannelly CM, et al: Increasing incidence of primary brain lymphoma in the US. Cancer 62:2461–2465, 1988. 6. Essig M, Schlemmer HP, Tronnier V, et al: Fluid-attenuated inversion-recovery MR imaging of gliomatosis cerebri. Eur Radiol 11:303–308, 2001.

Once irradiation is completed, postirradiation imaging should be performed to assess tumor response to radiation and any immediate radiation-related complications, such as edema, mass effect, or hemorrhage. Imaging at this time can also serve as a baseline scan before the patient starts adjuvant chemotherapy. For those patients enrolled in therapeutic clinical trials, a regular follow-up clinical and imaging evaluation is performed as part of the protocol—usually at intervals of 2 to 3 months, depending on the patient’s clinical status.

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