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The Pathophysiologic Basis of Nuclear Medicine (3rd Edition)

This ebook, now in its 3rd version, goals to advertise a deeper realizing of the clinical and medical foundation of nuclear drugs and the recent instructions in scientific imaging. the hot version has been revised and up to date to mirror fresh adjustments and to make sure that the contents are in response to most likely destiny instructions. The publication starts off by way of offering crucial info on common pathophysiology, telephone constitution and mobilephone biology in addition to the mechanisms of radiopharmaceutical localization in several tissues and cells. The scientific purposes of nuclear drugs are then awarded in a chain of chapters that disguise each significant organ process and relate the fundamental wisdom of anatomy, body structure and pathology to the scientific usage of assorted scintigraphic modalities. The healing functions of nuclear drugs are mentioned in a separate bankruptcy, and the ultimate bankruptcy is dedicated to the biologic results of ionizing radiations, together with radiation from scientific systems.

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Extra resources for The Pathophysiologic Basis of Nuclear Medicine (3rd Edition)

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The main function of the nucleolus is to form granular subunits of ribosomes, which are transported into the cytoplasm where they play an essential role in the formation of cellular proteins. 1 DNA: The Genetic Material The ability of cells to maintain a high degree of order depends on the hereditary or genetic information that is stored in the genetic material, the DNA. Within the nucleus of all mammalian cells a full complement of genetic information is stored, and the entire DNA is packaged into 23 pairs of chromosomes.

Normal Growth .......................................... Malignant Growth ...................................... 2 Cell-to-Cell Communication ................... Cell–Cell Interaction .................................. Cell Signaling and Cellular Receptors ....... 2 Cellular Metabolism ................................ Role of ATP ............................................... Production of ATP ..................................... 3 Transport Through the Cell Membrane.........................................

Point mutations cause changes in the hereditary message of an organism and may result from physical or chemical damage to the DNA or from spontaneous errors during replication. Frameshift mutation involves spontaneous mispairing and may result from insertion or deletion of a base pair. Mutational damage to DNA is generally caused by one of three events: (a) ionizing radiation causes double-stranded breaks in DNA due to the action of free radicals on phosphodiester bonds, (b) ultraviolet radiation creates DNA cross-links due to the absorption of UV energy by pyrimidines, and (c) chemical mutagens modify DNA bases and alter basepairing behavior.

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